Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in human immunoglobulin heavy chain variable genes and their upstream regions.

Nucleic acids research - 4 Jun 2020

Mikocziova Ivana, Gidoni Moriah, Lindeman Ida, Peres Ayelet, Snir Omri, Yaari Gur, Sollid Ludvig M

Abstract excerpt

Germline variations in immunoglobulin genes influence the repertoire of B cell receptors and antibodies, and such polymorphisms may impact disease susceptibility. However, the knowledge of the genomic variation of the immunoglobulin loci is scarce. Here, we report 25 potential novel germline IGHV alleles as inferred from rearranged naïve B cell cDNA repertoires of 98 individuals. Thirteen novel alleles were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Codon, Initiator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Variable Region

Share to Molecular Sequence Annotation

Share to Polymorphism, Genetic

Share to Sequence Analysis, DNA

Share to TATA Box

Source

Open in PubMed Open full text

Identifiers

PMID: 32365177
DOI: 10.1093/nar/gkaa310
PMCID: PMC7261178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in human immunoglobulin heavy chain variable genes and their upstream regions.PMID 32365177Read ↗

Polymorphisms in immunoglobulin heavy chain variable genes and their upstream regionsSemantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsSemantic proximity Read ↗

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.Semantic proximity Read ↗

Germline polymorphisms and alternative splicing of human immunoglobulin light chain genesSemantic proximity Read ↗

Discovery of 10,828 new putative human immunoglobulin heavy chain IGHV variantsSemantic proximity Read ↗

Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.Semantic proximity Read ↗

Alternative splice variants and germline polymorphisms in human immunoglobulin light chain genesSemantic proximity Read ↗

The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.Semantic proximity Read ↗

IMGT® Analysis of the Human IGH Locus: Unveiling Novel Polymorphisms and Copy Number Variations in Genome Assemblies from Diverse Ancestral BackgroundsSemantic proximity Read ↗

Computational Inference, Validation, and Analysis of 5'UTR-Leader Sequences of Alleles of Immunoglobulin Heavy Chain Variable Genes.Semantic proximity Read ↗

The Human Immunoglobulin Heavy Variable GenesSemantic proximity Read ↗

Population matched (PM) germline allelic variants of immunoglobulin ( <i>IG</i> ) loci: New pmIG database to better understand <i>IG</i> repertoire and selection processes in disease and vaccinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.