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Accumulation dynamics of defective genomes during experimental evolution of two betacoronaviruses

2024-02-08

Abstract excerpt

Virus-encoded replicases often generate aberrant RNA genomes, known as defective viral genomes (DVGs). When coinfected with a helper virus providing necessary proteins, DVGs can multiply and spread. While DVGs depend on the helper virus for propagation, they can disrupt infectious virus replication, impact immune responses, and affect viral persistence or evolution. Understanding the dynamics of DVGs alongside sta...

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Literature Corpus work
8621e6b7-a86b-5b96-b00f-a95ec7c90cad
DOI
10.1101/2024.02.06.579167
Open publication

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Accumulation dynamics of defective genomes during experimental evolution of two betacoronavirusesDOI 10.1101/2024.02.06.579167
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