Article

Influenza A virus defective viral genomes are inefficiently packaged into virions relative to wild-type genomic RNAs

2021-05-15

Abstract excerpt

Deletion-containing viral genomes (DelVGs) are commonly produced during influenza A virus infection and have been implicated in influencing clinical infection outcomes. Despite their ubiquity, the specific molecular mechanisms that govern DelVG formation and their packaging into defective interfering particles (DIPs) remain poorly understood. Here, we utilized next-generation sequencing to analyze DelVGs that form...

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Literature Corpus work: 6f6ac4cc-f1f4-51be-84f0-62ca265c222e
DOI: 10.1101/2021.05.13.444068

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