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Article

Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.

PLoS pathogens - 6 May 2010

Eckerle Lance D, Becker Michelle M, Halpin Rebecca A, Li Kelvin, Venter Eli, Lu Xiaotao, Scherbakova Sana, Graham Rachel L, Baric Ralph S, Stockwell Timothy B, Spiro David J, Denison Mark R

Abstract excerpt

Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not known how viruses encoding large viral RNA genomes such as the Coronaviridae (26 to 32 kb) balance the requirements for genome stability and quasispecies diversity. Further, the limits of replication...

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Identifiers

PMID: 20463816
DOI: 10.1371/journal.ppat.1000896
PMCID: PMC2865531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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