Article

Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection

2022-09-23

Abstract excerpt

Defective viral genomes (DVGs) have been identified in many RNA viruses as a major factor influencing antiviral immune response and viral pathogenesis. However, the generation and function of DVGs in SARS-CoV-2 infection are less known. In this study, we elucidated DVG generation in SARS-CoV-2 and its relationship with host antiviral immune response. We observed DVGs ubiquitously from RNA-seq datasets of in vitro...

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Literature Corpus work: 026b442c-9cc5-55a7-be2e-54112bad0aee
DOI: 10.1101/2022.09.22.509123

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