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SARS-CoV-2 Defective Viral Genomes from Distinct Genomic Regions Drive Divergent Interferon Responses

2026-03-24

Abstract excerpt

Defective viral genomes (DVGs) are naturally generated during genomic replication of many RNA viruses. When produced early in infection or supplemented at the onset of infection, DVGs can attenuate viral pathogenesis by stimulating IFN responses and antagonizing wild type (WT) virus replication, highlighting their potential as antiviral therapeutics. However, during natural infection DVGs can exert both antiviral...

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Literature Corpus work
2e01aacc-818c-5e3c-933e-988340bdac98
DOI
10.64898/2026.03.19.712870
Open publication

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SARS-CoV-2 Defective Viral Genomes from Distinct Genomic Regions Drive Divergent Interferon ResponsesDOI 10.64898/2026.03.19.712870
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