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Accumulation Dynamics of Defective Genomes during Experimental Evolution of Two Betacoronaviruses

20 Apr 2024

Abstract excerpt

Virus-encoded replicases often generate aberrant RNA genomes, known as defective viral genomes (DVGs). When co-infected with a helper virus providing necessary proteins, DVGs can multiply and spread. While DVGs depend on the helper virus for propagation, they can in some cases disrupt infectious virus replication, impact immune responses, and affect viral persistence or evolution. Understanding the dynamics of...

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PMID: 38675984
DOI: 10.3390/v16040644

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