Article

Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference

2025-11-03

Abstract excerpt

The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversity is the ubiquitous production of deletion-containing viral genomes (DelVGs) – viral RNAs with large internal deletions that arise during replication. DelVGs directly compete with wild-type (WT) genomes, and their ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01f287b8-56d0-5fb1-883d-9c5a6b45f574
DOI: 10.1101/2025.11.03.686333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interferenceDOI 10.1101/2025.11.03.686333Read

Influenza A genomic diversity during human infections underscores the strength of genetic drift and the existence of tight transmission bottlenecksSemantic proximity Read

The Dynamics of Influenza A H3N2 Defective Viral Genomes from a Human Challenge StudySemantic proximity Read

Influenza A genomic diversity during human infections underscores the strength of genetic drift and the existence of tight transmission bottlenecksSemantic proximity Read

Population Diversity and Collective Interactions during Influenza Virus Infection.Semantic proximity Read

Influenza A virus defective viral genomes are inefficiently packaged into virions relative to wild-type genomic RNAsSemantic proximity Read

Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteomeSemantic proximity Read

Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapySemantic proximity Read

Evolution of Influenza A Virus by Mutation and Re-Assortment.Semantic proximity Read

A general and biomedical perspective of viral quasispecies.Semantic proximity Read

Excessive production and extreme editing of human metapneumovirus defective interfering RNA is associated with type I IFN inductionSemantic proximity Read

Drivers of within-host genetic diversity in acute infections of viruses.Semantic proximity Read

Influenza Virus Genomic Mutations, Host Barrier and Cross-species TransmissionSemantic proximity Read