Article
The role of complement iC3b in dense deposit disease
2015-01-01
Abstract excerpt
Dense deposit disease (DDD) is a rare, progressive and incurable kidney disease characterized by complement C3 accumulation along the glomerular basement membrane (GBM). It is the prototypical form of C3 glomerulopathy, which comprises renal disorders due to excessive C3 activation via the alternative pathway (AP). Human and murine studies indicate that renal inflammation in DDD is initiated by the specific C3 act...
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Identifiers and source
- Literature Corpus work
- 861cc6b6-54c7-52b2-8582-11f579d4e2e6
- DOI
- 10.25560/34384