Article
Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies.
Kidney international - 1 Aug 2012
Servais Aude, Noël Laure-Hélène, Roumenina Lubka T, Le Quintrec Moglie, Ngo Stephanie, Dragon-Durey Marie-Agnès, Macher Marie-Alice, Zuber Julien, Karras Alexandre, Provot François, Moulin Bruno, Grünfeld Jean-Pierre, Niaudet Patrick, Lesavre Philippe, Frémeaux-Bacchi Véronique
Abstract excerpt
Dense deposit disease and glomerulonephritis with isolated C3 deposits are glomerulopathies characterized by deposits of C3 within or along the glomerular basement membrane. Previous studies found a link between dysregulation of the complement alternative pathway and the pathogenesis of these diseases. We analyzed the role of acquired and genetic complement abnormalities in a cohort of 134 patients, of whom 29...
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