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Development and Validation of a Centrosome Amplification-Related Prognostic Model in Pancreatic Cancer: Multi-Omics Guided Risk Stratification and Tumor Microenvironment

2025-08-12

Abstract excerpt

<h4>Background: </h4> Centrosome amplification, a hallmark of cell cycle dysregulation, drives carcinogenesis through aneuploidy induction and invasive phenotype acquisition. In pancreatic adenocarcinoma– a malignancy characterized by profound genomic instability – the molecular circuitry of centrosome amplification remains enigmatic. Critical gaps persist in understanding its spatiotemporal dynamics in tumor micr...

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Literature Corpus work
ddcc8582-00a5-5795-98ad-6fb3863a6e86
DOI
10.20944/preprints202508.0803.v1
Open publication

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Development and Validation of a Centrosome Amplification-Related Prognostic Model in Pancreatic Cancer: Multi-Omics Guided Risk Stratification and Tumor MicroenvironmentDOI 10.20944/preprints202508.0803.v1
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