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Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

6 Mar 2018

Abstract excerpt

Triple negative breast cancers (TNBCs) lack recurrent targetable driver mutations but demonstrate frequent copy number aberrations (CNAs). Here, we describe an integrative genomic and RNAi-based approach that identifies and validates gene addictions in TNBCs. CNAs and gene expression alterations are integrated and genes scored for pre-specified target features revealing 130 candidate genes. We test functional...

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PMID: 29535384
DOI: 10.1038/s41467-018-03283-z

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