Article

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP1 signaling in dormant disseminated uveal melanoma

2024-03-08

Abstract excerpt

Uveal melanoma (UM) can remain in clinical dormancy for decades only to later produce lethal metastases. Using Gαq/11 mut /BAP1 wt UM xenograft models and human metastatic samples, we identified NR2F1 as a key inducer of UM disseminated cancer cell (DCC) dormancy. Dormant UM DCCs upregulate NR2F1, neural crest genes and, along with suppression of proliferation programs, NR2F1 silences YAP1/TEAD1 transcription by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85be1579-233a-574c-bce3-455a8638c8d9
DOI: 10.1101/2024.03.05.583565

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP1 signaling in dormant disseminated uveal melanomaDOI 10.1101/2024.03.05.583565Read

Midkine Drives Reawakening of Dormant Melanoma MetastasesSemantic proximity Read

A comprehensive single cell atlas of healthy ocular tissue and uveal melanoma reveals mutation- and uveal tract-associated cell statesSemantic proximity Read

Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual DiseaseSemantic proximity Read

A Mesenchymal-like Program of Dormancy controlled by ZFP281 Serves as a Barrier To Metastatic Progression of Early Disseminated Cancer CellsSemantic proximity Read

NR2F1, a Tumor Dormancy Marker, Is Expressed Predominantly in Cancer-Associated Fibroblasts and Is Associated with Suppressed Breast Cancer Cell ProliferationSemantic proximity Read

BMP-dependent oligoclonal cancer attractor state precedes neural crest fate in melanoma initiationSemantic proximity Read

Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in BAP1 mut uveal melanomaSemantic proximity Read

Epigenetic plasticity in metastatic dormancy: mechanisms and therapeutic implicationsSemantic proximity Read

Clonal determinants of organotropism and survival in metastatic uveal melanomaSemantic proximity Read

Super-Enhancers Orchestrate Transcriptional Dysregulation and Metabolic Reprogramming in Uveal MelanomaSemantic proximity Read

Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma.Semantic proximity Read

Deciphering a common code: Unitary gene profile factor enabling Spontaneous Tumor RegressionSemantic proximity Read