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Article

Epigenetic plasticity in metastatic dormancy: mechanisms and therapeutic implications

1 Jul 2020

Abstract excerpt

The overwhelming majority of cancer-associated morbidity and mortality can be ascribed to metastasis. Metastatic disease frequently presents in a delayed fashion following initial diagnosis and treatment, requiring that disseminated cancer cells (DCCs) spread early in tumor progression and persist in a dormant state at metastatic sites. To accomplish this feat, DCCs exhibit substantial phenotypic plasticity that...

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PMID: 32793747
DOI: 10.21037/atm.2020.02.177

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