Article

Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in <i>BAP1</i> <sup> <i>mut</i> </sup> uveal melanoma

2025-04-18

Abstract excerpt

Uveal melanoma is the most prevalent primary intraocular cancer, with a significant metastatic risk. This risk is dependent on the genetic drivers. Secondary mutations in EIF1AX, SF3B1 and BAP1 correlate with clinical outcomes and are recognized for their distinct transcriptomic and epigenetic profiles. Previously, we identified 480 genes involved in the development of ocular melanocytes. Top ranking genes RBFOX...

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Literature Corpus work: 968ab686-9381-5604-a20f-d3b8d53ad420
DOI: 10.1101/2025.04.14.648661

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