Article
Midkine Drives Reawakening of Dormant Melanoma Metastases
2025-05-31
Abstract excerpt
<h4>ABSTRACT</h4> A major challenge in melanoma treatment is the emergence of aggressive metastases from previously dormant disseminated cancer cells (DCCs). Here we identify Midkine (MDK) as a key factor that disrupts melanoma DCC dormancy by triggering an autocrine signal that suppresses the dormancy inducer NR2F1 and alters the p-p38/p-ERK ratio, via ALK signaling. Dormant melanoma DCCs in lymph nodes and visc...
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Identifiers and source
- Literature Corpus work
- d5eb0419-fcf0-5e7c-84f9-34e1dbf7078b
- DOI
- 10.1101/2025.05.27.656365