Article

BMP-dependent oligoclonal cancer attractor state precedes neural crest fate in melanoma initiation

2024-10-25

Abstract excerpt

Field cancerization posits that groups of cells harboring oncogenic mutations create a permissive landscape predisposed to malignant transformation. We previously identified rare single cells in BRAF V600E ;p53 -/- zebrafish that reactivate an embryonic neural crest program prior to melanoma initiation. Here, we identify a specific field of BRAF V600E ;p53 -/- melanocytes with altered differentiation, morpholo...

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Identifiers and source

Literature Corpus work: dcfb1aec-60d9-5dfc-b555-ead5eaf5503c
DOI: 10.1101/2024.10.22.618007

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