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Article

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment.

International journal of molecular medicine - 1 Jul 2026

Song Shi-Na, Wu Jun-Ying, Song Mao-Mei, Li Xiao-Feng, Wang Jian-Ming, Jia Wen-Hui, Li Chang-Xin, Xu Sui-Yi

Abstract excerpt

Heterozygous high temperature requirement serine peptidase A1 (HTRA1) mutations are associated with autosomal dominant cerebral small vessel disease (CSVD), but their pathogenic mechanisms remain elusive. In the present study, clinical data were collected from two families carrying heterozygous HTRA1 mutations, with pathogenic mutations verified through Sanger sequencing. Between January 2018 and December 2023,...

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Source

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Identifiers

PMID: 42169653
DOI: 10.3892/ijmm.2026.5865
PMCID: PMC13215333

Genes

NOX4
HTRA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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