Article

Analysis of systemic epigenetic alterations in inflammatory bowel disease: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome

2021-05-27

Abstract excerpt

<title>Abstract</title> <p>Gene-environment interactions play a pivotal role in the pathogenesis of Inflammatory Bowel Disease (IBD). Using the IBD Character inception cohort (295 controls, 154 CD, 161 UC, 28 IBD-U) we confirm the presence of a highly characteristic DNA methylation profile in peripheral blood implicating 137 differentially methylated positions (DMP) in IBD, including <italic>VMP1/MIR21</italic> (...

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Literature Corpus work: 1b4db3ba-6223-5901-83b9-17c10d93649b
DOI: 10.21203/rs.3.rs-537439/v1

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