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Multi-Omics Analysis Reveals Intratumor Microbes as Immunomodulators in Colorectal Cancer

14 Feb 2023

Abstract excerpt

Using the multi-omics data from The Cancer Genome Atlas (TCGA) colorectal cancer (CRC) cohort, we estimated the tumor microenvironment (TME) infiltration patterns of patients and unraveled the interplay of gene expression, epigenetic modification, and the intratumor microbiome. This study suggests the impact of intratumor microbes on maintaining the tumor immune microenvironment in the pathogenesis of CRC and...

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PMID: 36786568
DOI: 10.1128/spectrum.05038-22

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