Article

Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer

2025-04-02

Abstract excerpt

<h4>Background: </h4> The incidence of colorectal cancer (CRC) in young adults (age of diagnosis < 50 years old) has been rapidly increasing. Although ~20% of early-onset (EO) CRC cases are due to germline mutations, the etiology of the majority of EOCRC cases remains poorly understood. Non-genetic factors such as environmental exposure and lifestyle changes are likely to have a direct link to the increased incide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8dc1316-1051-589c-98a7-1c7199f3f13b
DOI: 10.1101/2025.03.28.645992

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal CancerDOI 10.1101/2025.03.28.645992Read

Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.Semantic proximity Read

Colorectal cancer: The epigenetic role of microbiomeSemantic proximity Read

Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer developmentSemantic proximity Read

Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care.Semantic proximity Read

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.Semantic proximity Read

Single-cell integration analysis reveals molecular signatures of the tumor microenvironment in early-onset colorectal cancerSemantic proximity Read

Decoding the genetic and environmental forces in propelling the surge of early-onset colorectal cancerSemantic proximity Read

Genetic heterogeneity of colorectal cancer and the microbiomeSemantic proximity Read

The Enteric Microbiome in Early-Onset Colorectal Cancer: A Comprehensive Review of Its Role as a Biomarker of DiseaseSemantic proximity Read

Methylation-Guided Stratification of Colorectal Cancer Reveals Immune Subtypes with Distinct Clinical OutcomesSemantic proximity Read

Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic ImplicationsSemantic proximity Read

Multi-Omics Analysis Reveals Intratumor Microbes as Immunomodulators in Colorectal CancerSemantic proximity Read