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HMGA1-TRIP13 Axis Promotes Stemness and Epithelial Mesenchymal Transition of Perihilar Cholangiocarcinoma in a Positive Feedback Loop Dependent on C-Myc

2021-01-25

Abstract excerpt

<h4>Background: </h4> Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of radiotherapy and chemotherapy of pCCA are very limited. <h4>Methods: </h4> Here we screened potential biomarkers of pCCA with transcriptome sequencing and...

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Literature Corpus work
4d022a50-8968-54f7-8d2e-c32e7dfaf556
DOI
10.21203/rs.3.rs-152457/v1
Open publication

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HMGA1-TRIP13 Axis Promotes Stemness and Epithelial Mesenchymal Transition&nbsp;of Perihilar Cholangiocarcinoma in a Positive Feedback Loop Dependent on C-MycDOI 10.21203/rs.3.rs-152457/v1
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