Article

Site-Specific Nanobody Inhibitors of the Proteasomal Deubiquitinase UCH37

2025-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of the ubiquitin (Ub) proteasome system (UPS) is linked to numerous human diseases, making its components attractive therapeutic targets. Among these, the proteasomal deubiquitinase UCH37 (also known as UCHL5) has two distinct Ub-processing activities: C-terminal Ub hydrolysis and K48-linkage–specific chain debranching. Separating these activities has not been possible with existin...

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Literature Corpus work: 8584557b-dfc8-5e79-bfed-e08018c40f08
DOI: 10.1101/2025.08.11.669711

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