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Article

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

Nature chemical biology - 1 Jan 2013

Zhang Yingnan, Zhou Lijuan, Rouge Lionel, Phillips Aaron H, Lam Cynthia, Liu Peter, Sandoval Wendy, Helgason Elizabeth, Murray Jeremy M, Wertz Ingrid E, Corn Jacob E

Abstract excerpt

Protein conformation and function are often inextricably linked, such that the states a protein adopts define its enzymatic activity or its affinity for various partners. Here we combine computational design with macromolecular display to isolate functional conformations of ubiquitin that tightly bind the catalytic core of the oncogenic ubiquitin-specific protease 7 (USP7) deubiquitinase. Structural and...

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Source

Identifiers

PMID: 23178935
DOI: 10.1038/nchembio.1134

Genes

USP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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