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Article

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

Molecular cell - 5 Mar 2015

Sahtoe Danny D, van Dijk Willem J, El Oualid Farid, Ekkebus Reggy, Ovaa Huib, Sixma Titia K

Abstract excerpt

Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. Their activities are tightly regulated, but the mechanisms remain elusive. In particular, the DUB UCH-L5 can be either activated or inhibited by conserved regulatory proteins RPN13 and INO80G, respectively. Here we show how the DEUBAD domain in RPN13 activates UCH-L5 by positioning its C-terminal ULD domain and...

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Identifiers

PMID: 25702870
DOI: 10.1016/j.molcel.2014.12.039
PMCID: PMC4352763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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