Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processes

Abstract excerpt

Branched ubiquitin (Ub) chains make up a significant proportion of Ub polymers in human cells and are formed when two or more sites on a single Ub molecule are modified with Ub creating bifurcated architectures. Despite their abundance, we have a poor understanding of the cellular functions of branched Ub signals that stems from a lack of facile tools and methods to study them. Here we develop a comprehensive pipe...

Topics

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• Autophagy in Disease and Therapy
• Catalytic Domain
• Ectodermal Dysplasia
• I-kappa B Kinase
• Protein Domains
• Ubiquitin
• Ubiquitin and proteasome pathways
• Ubiquitination

Identifiers and source

Literature Corpus work

1708552f-4892-5566-b450-883212bece23

DOI

10.1101/2023.01.10.523363