Article

Conformation-specific Antibody Deciphers K27-linked Ubiquitination in Chaperone-Mediated Proteostasis

2025-12-18

Abstract excerpt

<h4>Summary</h4> Lysine 27 (K27)-linked polyubiquitination plays critical yet incompletely defined roles in proteostasis, innate immunity, and disease progression; however, investigations into this process have long been hindered by its extremely low abundance and the lack of conformation-specific enrichment tools. Herein, we describe the development of a long-sought conformation-specific antibody, K27-IgG, which...

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Literature Corpus work: 06c026c2-cf17-599f-bb71-6de960ac9691
DOI: 10.64898/2025.12.18.695067

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