Article

Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals

2024-11-15

Abstract excerpt

The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and f...

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Literature Corpus work: 0226f82f-8c9d-53b2-8719-99a9e240d4e9
DOI: 10.1101/2024.11.15.623737

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