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Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.

Biochemistry - 22 Sept 2020

Hewitt Chad S, Krabill Aaron D, Das Chittaranjan, Flaherty Daniel P

Abstract excerpt

Ubiquitin (Ub) is a highly conserved protein that is covalently attached to substrate proteins as a post-translational modification to regulate signaling pathways such as proteasomal degradation and cell cycle/transcriptional regulation in the eukaryotic cellular environment. Ub signaling is regulated by the homeostasis of substrate protein ubiquitination/deubiquitination by E3 ligases and deubiquitinating...

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PMID: 32865982
DOI: 10.1021/acs.biochem.9b01076

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