Article

TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy

2023-02-06

Abstract excerpt

Transcription factor EB (TFEB) mediates gene expression through binding to the C oordinated L ysosome E xpression A nd R egulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase) essential for lysosome acidification. Single nucleus RNA-sequencing (snRNA-seq) of wild-type and PS19 (Tau) transgenic mice identified three unique microglia subclusters in Tau mice that were associa...

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Literature Corpus work: 8582a204-720d-532c-aecc-90dec514a57c
DOI: 10.1101/2023.02.06.527293

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