Article

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons

2025-04-23

Abstract excerpt

Lysosomal dysfunction occurs in many neurodegenerative diseases, including Parkinson’s disease, and activating TFEB to enhance lysosomal biogenesis is a promising therapeutic strategy. To understand TFEB physiology in cells of the brain, we characterised TFEB expression using iPSC-derived models, and transcriptomic analysis of human and mouse brain tissue. Surprisingly, TFEB expression at the RNA and protein level...

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Literature Corpus work: f8f74adf-bf17-51a6-aa0a-95d01f920540
DOI: 10.1101/2025.04.22.649949

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