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Article

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

1 Nov 2020

Abstract excerpt

Transcription factor EB (TFEB) activates lysosomal biogenesis genes in response to environmental cues. Given implications of impaired TFEB signaling and lysosomal dysfunction in metabolic, neurological, and infectious diseases, we aim to systematically identify TFEB-directed circuits by examining transcriptional responses to TFEB subcellular localization and stimulation. We reveal that steady-state nuclear TFEB...

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PMID: 33176151
DOI: 10.1016/j.celrep.2020.108371

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