Article

Histone H2AX Promotes Metastatic Progression by Preserving Glycolysis via Hexokinase-2

2021-10-26

Abstract excerpt

Genomic stability is essential for organismal development, cellular homeostasis, and survival. The DNA double-strand breaks are particularly deleterious, creating an environment prone to cellular transformation and oncogenic activation. The histone variant H2AX is an essential component of the nucleosome responsible for initiating the early steps of the DNA repair process. H2AX maintains genomic stability by initi...

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Literature Corpus work: 85756bb2-3b12-5721-9414-432a4370d39e
DOI: 10.21203/rs.3.rs-991670/v1

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