Article

PKM2-mediated epigenetic reprogramming regulates hypoxic expression of <i>PFKFB3</i> to promote breast cancer progression

2022-11-07

Abstract excerpt

The hypoxic milieu is a critical modulator of aerobic glycolysis, yet the regulatory mechanisms existing between the key glycolytic enzymes in hypoxic cancer cells are largely unexplored. In particular, M2 isoform of pyruvate kinase (PKM2) − the ratelimiting enzyme of glycolysis, is well-known to confer adaptive advantages under hypoxia. Herein, we report a non-canonical role of PKM2 in functioning as a co-activat...

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Literature Corpus work: a230f319-8b43-54ac-bffe-deb0749f3328
DOI: 10.1101/2022.11.06.515384

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PKM2-mediated epigenetic reprogramming regulates hypoxic expression of <i>PFKFB3</i> to promote breast cancer progressionDOI 10.1101/2022.11.06.515384Read

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