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Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics

13 Dec 2018

Abstract excerpt

Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases (HKs), play crucial roles. Cancer cells are characterized by specific expression levels of several isoenzymes in different metabolic pathways and these features offer possibilities for therapeutic interventions. Overexpression of HKs (mostly of the HK2 isoform) have been consistently reported in numerous types of cancer....

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PMID: 30543165
DOI: 10.2174/0929867326666181213092652

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