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Targeting hexokinase 2 to induce breast cancer cell senescence

2025-02-25

Abstract excerpt

<h4>Background: </h4> and Purpose: Hexokinase 2 (HK2) is a key enzyme linked to high tumor cell proliferation. Its inhibitors such as 3-bromopyruvic acid (3-BP) induce cancer cell death, highlighting HK2 modulation as potential anti-cancer treatment. However, standard chemotherapies often cause the emergence of cellular senescence, which goes along with cell metabolic reprogramming and treatment failure. This stud...

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Literature Corpus work
8303025e-4325-5630-994d-a474f6df2d4c
DOI
10.22541/au.174046901.14415288/v1
Open publication

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Targeting hexokinase 2 to induce breast cancer cell senescenceDOI 10.22541/au.174046901.14415288/v1
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