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B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2

5 Apr 2019

Abstract excerpt

Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer (CRC) development. However, the underlying mechanisms have yet to be elucidated. B7-H3, an immunoregulatory protein, is broadly overexpressed by multiple tumor types and plays a vital role in tumor progression. In this study, we found that overexpression of B7-H3 effectively increased the rate of glucose consumption and...

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PMID: 30952834
DOI: 10.1038/s41419-019-1549-6

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