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Article

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

23 Mar 2015

Abstract excerpt

Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and initiate interferon regulatory factor-3 signaling, but it has been unclear how two DNA sensors could both be required for this response. We therefore investigated their relative roles in human foreskin fibroblasts (HFFs) infected with...

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PMID: 25831530
DOI: 10.1073/pnas.1424637112

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