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Isolation and manipulation of meiotic spindles from mouse oocytes reveals migration regulated by pulling force during asymmetric division

2024-12-08

Abstract excerpt

Spindles are essential for accurate chromosome segregation in all eukaryotic cells. This study presents a novel approach for isolating fresh mammalian spindles from mouse oocytes, establishing it as a valuable in vitro model system for a wide range of possible studies. Our method enables the investigation of the physical properties and migration force of meiotic spindles in oocytes. We found that the spindle leng...

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Literature Corpus work
855f8a2d-ad21-5684-b324-525293be6ff0
DOI
10.1101/2024.12.06.627260
Open publication

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Isolation and manipulation of meiotic spindles from mouse oocytes reveals migration regulated by pulling force during asymmetric divisionDOI 10.1101/2024.12.06.627260
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