Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1

22 Aug 2013

Abstract excerpt

Errors in chromosome segregation in oocytes and early embryos lead to embryo aneuploidy, which contributes to early pregnancy loss. At the heart of chromosome segregation is the spindle, a dynamic biomechanical machine fashioned from microtubules, which is tasked with gathering and sorting chromosomes and dispatching them to the daughter cells at the time of cell division. Understanding the causes of segregation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microtubule and mitosis dynamics
Share to Prenatal Screening and Diagnostics
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23966320
DOI: 10.1095/biolreprod.113.112151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1PMID 23966320Read ↗

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imagingSemantic proximity Read ↗

Chromosome Segregation in the Oocyte: What Goes Wrong during AgingSemantic proximity Read ↗

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errorsSemantic proximity Read ↗

Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1Semantic proximity Read ↗

Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproductionSemantic proximity Read ↗

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytesSemantic proximity Read ↗

Actin protects mammalian eggs against chromosome segregation errorsSemantic proximity Read ↗

Aneuploidy in human eggs: contributions of the meiotic spindleSemantic proximity Read ↗

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase BSemantic proximity Read ↗

Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?Semantic proximity Read ↗

Kinetochore microtubule establishment is defective in oocytes from aged miceSemantic proximity Read ↗

Meiotic spindle formation in mammalian oocytes: implications for human infertility†Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.