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Article

Positioning to get out of meiosis: the asymmetry of division

9 Sept 2010

Abstract excerpt

BACKGROUND: During meiosis, mammalian oocytes undergo two successive cell divisions without an intermediate replicative phase. This brief period, called 'meiotic maturation', is crucial for the formation of an egg capable of being fertilized and of generating viable and euploid offspring. METHODS: We review our current knowledge of the cellular and molecular mechanisms that control asymmetry and appear to be...

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PMID: 20833637
DOI: 10.1093/humupd/dmq044

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