Article

Identification of Repurposable Cytoprotective Drugs in Vanishing White Matter Disease Patient-Derived cells

2020-08-04

Abstract excerpt

<title>Abstract</title> <p>BackgroundVanishing white matter disease (VWMD) is a rare leukodystrophy caused by mutations of the guanine exchange factor eIF2B that typically presents with juvenile onset. There are few treatments and no cures for the disease. Recent progress in the field has established mitochondrial dysfunction and endoplasmic reticulum (ER) stress to be strongly implicated in observed glial cell p...

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Literature Corpus work: 2e514c0b-1a62-501a-aff7-7452b971b084
DOI: 10.21203/rs.3.rs-48008/v1

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