Article

Identification of repurposable cytoprotective drugs in Vanishing White Matter Disease patient-derived cells

2020-10-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Vanishing white matter disease (VWMD) is a rare leukodystrophy caused by mutations of the guanine exchange factor eIF2B. VWMD typically presents with juvenile onset, and there are few treatments for the disease. Recent progress in the field has established mitochondrial dysfunction and endoplasmic reticulum (ER) stress to be strongly implicated in observed glial...

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Literature Corpus work: 02ef8376-a372-5f57-b340-294aacac2ed9
DOI: 10.21203/rs.3.rs-61811/v2

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