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Article

Phenotypic assays to identify agents that induce reactive gliosis: a counter-screen to prioritize compounds for preclinical animal studies.

Assay and drug development technologies - 1 Sept 2015

Beckerman Samuel R, Jimenez Joaquin E, Shi Yan, Al-Ali Hassan, Bixby John L, Lemmon Vance P

Abstract excerpt

Astrocyte phenotypes change in a process called reactive gliosis after traumatic central nervous system (CNS) injury. Astrogliosis is characterized by expansion of the glial fibrillary acidic protein (GFAP) cytoskeleton, adoption of stellate morphologies, and differential expression of some extracellular matrix molecules. The astrocytic response immediately after injury is beneficial, but in the chronic injury...

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Source

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Identifiers

PMID: 26230074
DOI: 10.1089/adt.2015.654
PMCID: PMC4555645

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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