Article

Mapping genetic effects on cellular phenotypes with “cell villages”

2020-06-29

Abstract excerpt

<h4>Summary</h4> Tens of thousands of genetic variants shape human phenotypes, mostly by unknown cellular mechanisms. Here we describe Census-seq, a way to measure cellular phenotypes in cells from many people simultaneously. Analogous to pooled CRISPR screens but for natural variation, Census-seq associates cellular phenotypes to donors’ genotypes by quantifying the presence of each donor’s DNA in cell “villages...

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Literature Corpus work: ff6dc4a2-9669-5e38-9eca-c73ad7e06ab9
DOI: 10.1101/2020.06.29.174383

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