Article

Longitudinal study of neurochemical, volumetric and behavioral changes in Q140 & BACHD mouse models of Huntington’s disease

2024-02-21

Abstract excerpt

Brain metabolites, detectable by magnetic resonance spectroscopy (MRS), have been examined as potential biomarkers in Huntington’s Disease (HD). In this study, the RQ140 and BACHD transgenic mouse models of HD were used to investigate the relative sensitivity of the metabolite profiling and the brain volumetry to characterize mouse HD. Magnetic resonance imaging (MRI) and 1H MRS data were acquired at 9.4 T from th...

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Literature Corpus work: 853fe71b-65b9-5d10-8b98-c60fa18b204c
DOI: 10.1101/2024.02.16.580735

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