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Article

Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Nov 2012

Tkac Ivan, Henry Pierre-Gilles, Zacharoff Lori, Wedel Michael, Gong Wuming, Deelchand Dinesh K, Li Tongbin, Dubinsky Janet M

Abstract excerpt

Impairment of energy metabolism is a key feature of Huntington disease (HD). Recently, we reported longitudinal neurochemical changes in R6/2 mice measured by in-vivo proton magnetic resonance spectroscopy ((1)H MRS; Zacharoff et al, 2012). Here, we present similar (1)H MRS measurements at an early stage in the milder Q111 mouse model. In addition, we measured the concentration of ATP and inorganic phosphate...

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Identifiers

PMID: 22805874
DOI: 10.1038/jcbfm.2012.104
PMCID: PMC3493992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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