Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

doi:10.1177/0271678X18756499

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Article

Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jul 2019

Lei Hongxia, Dirren Elisabeth, Poitry-Yamate Carole, Schneider Bernard L, Gruetter Rolf, Aebischer Patrick

Abstract excerpt

In vivo 1H magnetic resonance spectroscopy (1H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to longitudinally follow neurochemical evolutions of striatum, brainstem and motor cortex of mice transgenic for G93A mutant human superoxide dismutase type-1 (G93A-SOD1), an ALS model....

Topics

Amyotrophic Lateral Sclerosis
Animals
Ascorbic Acid
Aspartic Acid
Brain
Brain Chemistry
Brain Stem
Corpus Striatum
Disease Models, Animal
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamic Acid

Glutamine

Humans

Lactic Acid

Magnetic Resonance Spectroscopy

Mice

Mice, Transgenic

Motor Cortex

Source

Open in PubMed Open full text

Identifiers

PMID: 29400109
DOI: 10.1177/0271678X18756499
PMCID: PMC6668519

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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