Article

<i>In vivo</i> MR spectroscopy reflects synapse density in a Huntington’s disease mouse model

2021-10-28

Abstract excerpt

Striatal medium spiny neurons are highly susceptible in Huntington’s disease (HD), resulting in progressive synaptic perturbations that lead to neuronal dysfunction and death. Non-invasive imaging techniques, such as proton magnetic resonance spectroscopy ( 1 H-MRS), are used in HD mouse models and patients with HD to monitor neurochemical changes associated with neuronal health. However, the association between...

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Identifiers and source

Literature Corpus work: 1387ac86-70fe-5d9f-9fd2-185c781db642
DOI: 10.1101/2021.10.26.465951

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