Article
MicroRNAs in CD4(+) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes.
Journal of autoimmunity - 1 Apr 2016
Zhang Yuxia, Feng Zhi-Ping, Naselli Gaetano, Bell Fiona, Wettenhall James, Auyeung Priscilla, Ellis Justine A, Ponsonby Anne-Louise, Speed Terence P, Chong Mark M W, Harrison Leonard C
Abstract excerpt
MicroRNAs (miRNAs) regulate T cell development and function and the disruption of miRNAs in natural regulatory CD4(+) FOXP3(+) T cells (nTreg) leads to autoimmune disease in mice. To investigate miRNA expression in relation to autoimmune disease risk in humans we sequenced them in purified CD4(+) T cell subsets from individuals at high risk of type 1 diabetes (pre-T1D), as well as other healthy individuals....
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